further more illuminating issues, purpose and therapeutic efficacy of MSCs are highly controlled through the bordering niche/microenvironment (Zhu et al., 2016; Mehrbani Azar et al., 2018; Tejero et al., 2019; Gilchrist et al., 2021), and research on skeletal degenerative and autoimmune disorders have highlighted the essence of cell-host intera

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